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Double-negative T cells with a distinct transcriptomic profile are abundant in the peripheral blood of patients with breast cancer

10 Sept 2024

Abstract excerpt

BACKGROUND: Double-negative T (DNT) cells comprise a distinct subset of T lymphocytes that have been implicated in immune responses. The aim of this study was to characterize the peripheral DNT population in breast cancer (BC) patients. METHODS: DNT cells were isolated from the peripheral blood samples of BC patients and healthy controls by flow cytometry. The sorted DNT cells were analyzed by the Smart-seq2 for...

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PMID: 39254769
DOI: 10.1007/s10549-024-07477-6

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