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Protective function of <i>ex vivo</i> expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression

2024-03-17

Abstract excerpt

The adoptive transfer of virus-specific T cells (VSTs) represents a therapeutic option for viral infection treatment in immunocompromised patients. Before administration, ex vivo culture enables VST expansion. However, it is unclear how ex vivo expansion affects the circulation, homing, and intra-tissue migration of administered VSTs. We established a model of VST immunotherapy of acute cytomegalovirus infection...

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Literature Corpus work
a063aeb4-7939-590c-a745-59ea8b225484
DOI
10.1101/2024.03.16.585350
Open publication

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Protective function of <i>ex vivo</i> expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expressionDOI 10.1101/2024.03.16.585350
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