Article

Broad PFAS binding with fatty acid binding protein 4 is enabled by variable binding modes

2025-01-14

Abstract excerpt

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous pollutants that bioaccumulate in wildlife and humans, yet the molecular basis of their protein interactions remains poorly understood. Here, we show that human adipocyte fatty acid-binding protein (FABP4) can bind a diverse array of PFAS, including next-generation replacements for legacy chemicals and longer-chain perfluorocarboxylic acids. Shorter-chain PF...

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Literature Corpus work: a0541ff1-14a0-54bf-865d-e9096109eedb
DOI: 10.1101/2025.01.10.632451

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