Article

Synergistic interactions of mobile genetic elements shape the stepwise evolution of multidrug-resistant plasmids

2025-11-29

Abstract excerpt

Rising multidrug-resistant (MDR) bacteria threatens global public health. While antibiotic selection preserves MDR plasmids, how mobile genetic elements (MGEs) drive the antibiotic resistance gene (ARG) accumulation to form complex plasmid architectures remain elusive. Here, we demonstrate that MDR plasmid evolution follows a hierarchical scheme, where progressive combinations of integrons, IS26, and ISCR elements...

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Literature Corpus work: a044da13-7def-5532-904f-ed53dbfea461
DOI: 10.1101/2025.11.28.691237

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