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IS6 family insertion sequences promote optrA dissemination between plasmids varying in transfer abilities

15 Jan 2024

Abstract excerpt

Plasmids are the primary vectors for intercellular transfer of the oxazolidinone and phenicol cross-resistance gene optrA, while insertion sequences (ISs) are mobile genetic elements that can mobilize plasmid-borne optrA intracellularly. However, little is known about how the IS-mediated intracellular mobility facilitates the dissemination of the optrA gene between plasmid categories that vary in transfer...

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PMID: 38229329
DOI: 10.1007/s00253-023-12858-w

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