Article

Sequential intra-articular HCAd-NFκB-IL-1Ra delivery improves therapeutic efficacy in post-traumatic osteoarthritis

2026-07-28

Abstract excerpt

Osteoarthritis is the most common joint disease for which disease-modifying therapies remain unavailable. Intra-articular gene delivery of interleukin-1 receptor antagonist (IL-1Ra) using high-capacity adenovirus (HCAd) has shown therapeutic promise; however, the duration of therapeutic benefit and the feasibility of repeat dosing under anti-adenoviral immunity remain unresolved. Using the murine anterior cruciate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f615be15-7512-51b6-9908-62dbd143816e
DOI: 10.64898/2026.07.27.740818

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sequential intra-articular HCAd-NFκB-IL-1Ra delivery improves therapeutic efficacy in post-traumatic osteoarthritisDOI 10.64898/2026.07.27.740818Read

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directionsSemantic proximity Read

Navigating the Hurdles of Intra-articular AAV Gene TherapySemantic proximity Read

Comparative intra-articular gene transfer of seven adeno-associated virus serotypes reveals that AAV2 mediates the most efficient transduction to mouse arthritic chondrocytesSemantic proximity Read

Cross-Species Efficacy of Combinatorial Gene Therapy for Osteoarthritis and Correction of Neuro-Inflammatory Pain MechanismsSemantic proximity Read

A single versus multi-vector approach to treating post-traumatic osteoarthritis using scAAV2 IL-1ra or scAAV2 IL-1ra/IGF-I in an equine preclinical modelSemantic proximity Read

New treatment for osteoarthritis: Gene therapySemantic proximity Read

Gene Delivery to Joints by Intra-Articular InjectionSemantic proximity Read

Rationally engineered novel AAV capsids for intra-articular gene deliverySemantic proximity Read

Intra‐articular gene delivery and expression of interleukin‐1Ra mediated by self‐complementary adeno‐associated virusSemantic proximity Read

Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of OsteoarthritisSemantic proximity Read

Inflammation‐inducible anti‐TNF gene expression mediated by intra‐articular injection of serotype 5 adeno‐associated virus reduces arthritisSemantic proximity Read

Multi-Target Gene Therapy for Osteoarthritis: Dual-Axis Modeling and In Silico ValidationSemantic proximity Read