Article

SIRT1 Downregulation Contributes to Surgery-Induced Cognitive Impairment Through Autophagy-Mediated NLRP3 Inflammasome Activation in the Hippocampi of Aged Mice

2023-09-27

Abstract excerpt

Postoperative cognitive dysfunction (POCD) is characteristic of cognitive dysfunction in older people following anesthesia and surgery. There has remained a lack of clinical measures for effective prevention and treatment. Recent studies have shown that Sirtuin 1 (SIRT1), autophagy, and the NOD-like receptor protein 3 (NLRP3) inflammasomes are closely associated with the development of neurodegeneration. However,...

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Literature Corpus work: a0333403-39c8-5d5c-8421-9ba29fac56d5
DOI: 10.21203/rs.3.rs-3338315/v1

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