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Article

Aberrant phenotype in human endothelial cells of diabetic origin: implications for saphenous vein graft failure?

Journal of diabetes research - 1 Jan 2015

Roberts Anna C, Gohil Jai, Hudson Laura, Connolly Kyle, Warburton Philip, Suman Rakesh, O'Toole Peter, O'Regan David J, Turner Neil A, Riches Kirsten, Porter Karen E

Abstract excerpt

Type 2 diabetes (T2DM) confers increased risk of endothelial dysfunction, coronary heart disease, and vulnerability to vein graft failure after bypass grafting, despite glycaemic control. This study explored the concept that endothelial cells (EC) cultured from T2DM and nondiabetic (ND) patients are phenotypically and functionally distinct. Cultured human saphenous vein- (SV-) EC were compared between T2DM and ND...

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Identifiers

PMID: 25950006
DOI: 10.1155/2015/409432
PMCID: PMC4407531

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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