Article

Accelerated, Accurate, Hybrid Short and Long Reads Alignment and Variant Calling

2025-04-20

Abstract excerpt

<h4>Background</h4> Integrating short-read and long-read sequencing technologies has become a promising approach for achieving accurate and comprehensive genomic analysis. While short-read sequencing (Illumina, etc.) offers high base accuracy and cost efficiency, it struggles with structural variation (SV) detection and complex genomic regions. In contrast, long-read sequencing (PacBio HiFi) excels in resolving l...

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Literature Corpus work: a7854aae-ab42-5658-814b-7fb1bd77e8f5
DOI: 10.1101/2025.04.15.648987

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