Article

The E2F1 regulon orchestrates a proliferative emergency and vascular programming in fetal endothelial progenitors exposed to GDM: a sex-stratified systems medicine approach

2026-07-01

Abstract excerpt

Maternal Gestational Diabetes Mellitus (GDM) and obesity are major drivers of the Developmental Origins of Health and Disease (DOHaD), predisposing offspring to premature cardiovascular disease. However, the specific molecular pathways that program this sex-specific vascular risk remain poorly defined due to the cellular complexity of the placenta. We sought to identify the primary regulatory engines of fetal vasc...

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Literature Corpus work: 9f8b9bc9-2b5c-5c85-9550-483d998bfce5
DOI: 10.64898/2026.06.26.734910

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The E2F1 regulon orchestrates a proliferative emergency and vascular programming in fetal endothelial progenitors exposed to GDM: a sex-stratified systems medicine approachDOI 10.64898/2026.06.26.734910Read

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