High-fat diet induces pre-eclampsia like phenotypes associated with impaired decidualization and NF-κB activation.

Abstract excerpt

Pre-eclampsia (PE), a life-threatening hypertensive disorder of pregnancy, remains a leading cause of maternal-fetal morbidity with unclear pathogenesis. While traditional studies focus on placental dysfunction, the critical role of decidualization-a prerequisite for placental implantation-has been underemphasized. Here, we demonstrate that a high-fat diet (HFD) predisposes mice to PE-like phenotypes, including...

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