Article

A Phase I Study using Bortezomib (Velcade), Cladribine, and Rituximab (VCR) in Treating Elderly Patients with Mantle Cell Lymphoma

2024-03-27

Abstract excerpt

Cladribine indirectly downregulates methylations of DNA, RNA and histone by blocking transferring methyl groups from S-adenosyl-methionine. Cladribine and Rituximab combination showed a synergetic effect in treating B cell lymphomas. Bortezomib (Velcade) is a FDA approved proteasome inhibitor for treating mantle cell lymphoma (MCL). In this single arm phase I study, we evaluated the safety, dose limiting toxicity,...

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Literature Corpus work: 9f4b8805-aa1f-5105-9328-362c1907ec0e
DOI: 10.21203/rs.3.rs-4139215/v1

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