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The Roles of Placental Senescence, Autophagy and Senotherapeutics in the Development and Prevention of Pre-Eclampsia: A Focus on Ergothioneine

2025-04-15

Abstract excerpt

Cellular senescence is a well-established biological phenomenon in eukaryotes. It involves DNA damage, telomere shortening, a senescence-associated secretory phenotype (SASP), and the inability of cells to replicate. It is associated with ageing, and also with oxidative stress. Given the importance of oxidative stress in pre-eclampsia, there is considerable evidence, that we review, that senescence plays an import...

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Literature Corpus work
9f49a27e-cc02-5c0a-a80a-74ee219cd595
DOI
10.20944/preprints202504.1261.v1
Open publication

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