Article

Enteropathogenic <i>Escherichia coli</i> manipulates the host exocyst complex to enhance pedestal formation

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Enteropathogenic Escherichia coli (EPEC), a major cause of diarrheal disease, produces plasma membrane pedestals that promote colonization of host cells. Critical for pedestal formation is EPEC’s type III secretion system, which injects ∼ 20 effector proteins into human cells. One of these effectors is Tir, which inserts into the host plasma membrane and stimulates the assembly of actin filamen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f44a5d4-26d3-5309-be45-55fb2fe601a7
DOI: 10.1101/2025.09.18.677024

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enteropathogenic <i>Escherichia coli</i> manipulates the host exocyst complex to enhance pedestal formationDOI 10.1101/2025.09.18.677024Read

Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length.Semantic proximity Read

Intimate host attachment: enteropathogenic and enterohaemorrhagic<i>Escherichia coli</i>Semantic proximity Read

Exploitation of host cells by enteropathogenic <i>Escherichia</i> <i>coli</i>Semantic proximity Read

Why put yourself on a pedestal? The pathogenic role of the A/E pedestalSemantic proximity Read

EhRacM differentially regulates macropinocytosis and motility in the enteric protozoan parasite <i>Entamoeba histolytica</i>Semantic proximity Read

Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection.Semantic proximity Read

EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly.Semantic proximity Read

Enteropathogenic Escherichia coli (EPEC) attachment to epithelial cells: exploiting the host cell cytoskeleton from the outsideSemantic proximity Read

The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP)Semantic proximity Read

Cortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the alpha-helical region is involved in the localization of cortactin to bacterial attachment sites.Semantic proximity Read

EspF<sub>U</sub>, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7Semantic proximity Read

Activation of the type 3 secretion system of enteropathogenic <i>E. coli</i> leads to remodeling of its membrane composition and functionSemantic proximity Read