Article

Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

2018-09-13

Abstract excerpt

Accurate predictions of T-cell epitopes would be useful for designing vaccines, immunotherapies for cancer and autoimmune diseases, and improved protein therapies. The humoral immune response involves uptake of antigens by antigen presenting cells (APCs), APC processing and presentation of peptides on MHC class II (pMHCII), and T-cell receptor (TCR) recognition of pMHCII complexes. Most in silico methods predict...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ec471cb-f988-5c4c-98d5-d920ac0d310f
DOI: 10.1101/415661

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognitionDOI 10.1101/415661Read

Major histocompatibility complex linked databases and prediction tools for designing vaccines.Semantic proximity Read

NetCleave: an open-source algorithm for predicting C-terminal antigen processing for MHC-I and MHC-II.Semantic proximity Read

Definition of naturally processed peptides reveals convergent presentation of autoantigenic topoisomerase-I epitopes in sclerodermaSemantic proximity Read

Discovery of promiscuous HLA-II-restricted T cell epitopes with TEPITOPESemantic proximity Read

HLAIIPred: Cross-Attention Mechanism for Modeling the Interaction of HLA Class II Molecules with PeptidesSemantic proximity Read

TepiTool: A Pipeline for Computational Prediction of T Cell Epitope Candidates.Semantic proximity Read

INeo‐Epp: A Novel T‐Cell HLA Class‐I Immunogenicity or Neoantigenic Epitope Prediction Method Based on Sequence‐Related Amino Acid FeaturesSemantic proximity Read

Flexible machine learning prediction of antigen presentation for rare and common HLA-I allelesSemantic proximity Read

INeo-Epp: A novel T-cell HLA class-I immunogenicity or neoantigenic epitope prediction method based on sequence related amino acid featuresSemantic proximity Read

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligandsSemantic proximity Read

Effective assessment of CD4 <sup>+</sup> T cell Immunodominance patterns: impact of antigen processing and HLA restrictionSemantic proximity Read

T Cell Epitope PredictionsSemantic proximity Read