Article

The CD74 inhibitor DRhQ improves cognition and mitochondrial function in 5xFAD mouse model of Aβ accumulation

2024-01-30

Abstract excerpt

Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neurodegeneration and cognitive impairment. Evidence suggests that the inflammatory axis mediated by macrophage migration inhibitory factory (MIF) binding to its receptor, CD74, plays an important role in many central nervous system (CNS) disorders like AD. Our group has developed DRhQ, a novel CD74 bindi...

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Literature Corpus work: 9ea982d8-e779-5d7b-9ee7-2a527fed67c0
DOI: 10.1101/2024.01.29.577832

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