Article

ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an <i>in silico</i> study

2020-04-24

Abstract excerpt

The current SARS covid-19 epidemic spread appears to be influenced by ethnical, geographical and sex-related factors that may involve genetic susceptibility to diseases. Similar to SARS-CoV, SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells, notably type II alveolar epithelial cells. Importantly, ACE2 gene is highly polymorphic. Here we have used in silico tools to analyze t...

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Literature Corpus work: 9ea08f7b-724c-5814-99fe-c05e176bbf64
DOI: 10.1101/2020.04.23.057042

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