Article

HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators

2019-01-01

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year survival. Genetically, ccRCCs are characterised by inactivation of VHL which is lost in 90% of cases. Inactivating mutations of VHL lead to stabilisation of HIF2α which in turn drives the expression of multiple target genes involved in ccRCC initiation. However, it is unclear whether HIF2α activation is necessary fo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e81392c-41b3-5361-b3ee-5aefce38580c
DOI: 10.17863/cam.40950

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulatorsDOI 10.17863/cam.40950Read

Hypoxia-Inducible Factor 2-Dependent Pathways Driving Von Hippel–Lindau-Deficient Renal CancerSemantic proximity Read

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in miceSemantic proximity Read

The role of HIF1α in renal cell carcinoma tumorigenesis.Semantic proximity Read

Differential Effects of HIF2α Antagonist and HIF2α Silencing in Renal Cancer and Sensitivity to Repurposed DrugsSemantic proximity Read

VHL and HIF signalling in renal cell carcinogenesisSemantic proximity Read

Hypoxia-Inducible Factor in Renal Cell Carcinoma: From Molecular Insights to Targeted TherapiesSemantic proximity Read

Hypoxia-inducible factors drive miRNA-mediated downregulation of <i>L2HGDH</i> and <i>HIF1A</i> in clear cell renal cancer independent of 14q deletionSemantic proximity Read

Targeting renal cell carcinoma with a HIF-2 antagonist.Semantic proximity Read

Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell CarcinomaSemantic proximity Read

VHLinactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatmentSemantic proximity Read

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF SignalingSemantic proximity Read

Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathwaySemantic proximity Read