Article

Differential Effects of HIF2α Antagonist and HIF2α Silencing in Renal Cancer and Sensitivity to Repurposed Drugs

2021-02-25

Abstract excerpt

<h4>Background: </h4> in clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of the VHL gene, leading to constitutive activation of both HIF1α and HIF2α. As HIF2α is the driver of the disease promoting tumour growth and metastasis, drugs targeting HIF2α have been developed. However, resistance is common, therefore new therapies are needed. <h4>Methods: </h4> we assessed the effect of the HIF2...

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Literature Corpus work: 56693615-048c-5a2b-92f5-9ecf0282c11b
DOI: 10.21203/rs.3.rs-237320/v1

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