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Hippocampal-to-Ventricle Ratio as a Head-Size-Independent Biomarker: Sex Differences and Cognitive Associations in 27,680 UK Biobank Participants

2026-04-15

Abstract excerpt

Hippocampal volume is a key biomarker for Alzheimer’s disease and brain aging, yet reported sex differences vary substantially depending on head-size adjustment methods. We examined whether the hippocampal-to-ventricle ratio (HVR), a self-normalizing measure, provides more consistent sex difference estimates than conventional adjustment approaches. Using a subset of UK Biobank structural MRI data (N = 27,680; 56%...

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Literature Corpus work
a9c713a4-dc87-54e5-9c67-205951b5bc16
DOI
10.64898/2026.04.13.718285
Open publication

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Hippocampal-to-Ventricle Ratio as a Head-Size-Independent Biomarker: Sex Differences and Cognitive Associations in 27,680 UK Biobank ParticipantsDOI 10.64898/2026.04.13.718285
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