Article

Triptonide Effectively Inhibits Triple-Negative Breast Cancer Metastasis Through Concurrent Degradation Of Twist1 And Notch1 Oncoproteins

2021-07-15

Abstract excerpt

<h4>Background: </h4> Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic. <h4>Methods: </h4> We explored the ability of active compounds derived from natural herbs to inhibit TNBC metastasis using the methods of molecular biology, cell biology, protein chemistry, pharmacology, and xenografted mice...

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Literature Corpus work: 9e5aa670-914d-5af7-8ebe-808eba0e6ece
DOI: 10.21203/rs.3.rs-685427/v1

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