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Deletion of <i>CH25H</i> and <i>LIPA</i> Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant<sup>‡</sup>

2025-07-30

Abstract excerpt

The CH25H ( cholesterol 25-hyroxylase ) and LIPA ( lipase A, lysosomal acid type ) genes are contiguous genes on chromosome 10. CH25H is translated to cholesterol 25-hydroxylase which generates 25- hydroxycholesterol (25-HC) from cholesterol, while LIPA codes for lysosomal acid lipase (LAL) which hydrolyses cholesteryl esters in the endosome – lysosome compartment. Here we report the effect on the oxysterol patter...

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Literature Corpus work
9e487870-41a0-50bc-a0fb-7c82c839a014
DOI
10.1101/2025.07.29.25330953
Open publication

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Deletion of <i>CH25H</i> and <i>LIPA</i> Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant<sup>‡</sup>DOI 10.1101/2025.07.29.25330953
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