Effects of salvianolic acid A on β-amyloid mediated toxicity in <i>Caenorhabditis elegans</i> model of Alzheimer’s disease

Abstract excerpt

Alzheimer’s disease (AD) is a brain disease attributed to the accumulation of extracellular senile plaques comprising β-amyloid peptide (Aβ). In this study, a transgenic Caenorhabditis elegans containing the human beta amyloid Aβ 42 gene which exhibited paralysis when expressed, was used to study the anti-paralysis effect of salvianolic acid A. Various concentrations ranging from 1 μg/ml to 100 μg/ml of salviano...

Topics

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• Alzheimer Disease
• Caenorhabditis elegans
• Genetics, Aging, and Longevity in Model Organisms
• Oligonucleotide Array Sequence Analysis
• Oxidative Stress
• Reactive Oxygen Species
• Receptors, Tumor Necrosis Factor
• Receptors, Tumor Necrosis Factor, Type I

Identifiers and source

Literature Corpus work

9e443b2e-82c3-556e-abc2-7343025b7649

DOI

10.1101/2020.04.13.040170