Molecular pathology of acute spinal cord injury in middle-aged mice

Abstract excerpt

The median age of sustaining a spinal cord injury has steadily increased from 29 to 43 over the last several decades. Although more pre-clinical studies in aged rodents are being done to address this shift in demographics, there have not been comprehensive transcriptomic studies investigating SCI pathobiology in middle-aged mice. To address this gap in knowledge, we compared behavioral, histopathological, and tran...

Topics

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• Complement System Proteins
• Gene Regulatory Networks
• Lower Extremity
• Molecular Sequence Annotation
• Neuroinflammation and Neurodegeneration Mechanisms
• Receptors, Notch
• Support Vector Machine
• Wnt Proteins

Identifiers and source

Literature Corpus work

9e0b1a80-28c7-5ce3-8cc6-85354a9e8850

DOI

10.1101/2025.05.08.652873