Article

The impact of hypoxia on B cells in COVID-19

2021-07-15

Abstract excerpt

Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2. This brought to mind the phenotype of mice with VHL-deficient B cells, in which Hypoxia-Inducible Factors are constitutively active, suggesting hypoxia might drive B cell abnormalities in COVID-19. We demonstrated the breadth of early and p...

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Literature Corpus work: 9de375b3-2f61-5209-b816-f28fc68b8c41
DOI: 10.1101/2021.07.12.21260360

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