Article

Maternal Hepcidin Suppression Is Essential for Healthy Pregnancy

2020-11-05

Abstract excerpt

Iron is essential for maternal and fetal health during pregnancy, and iron requirements increase substantially in the second half of gestation1. However, the molecular mechanisms ensuring increased iron availability during pregnancy are not well understood. Hepcidin is the key iron-regulatory hormone and functions by occluding and degrading the iron exporter ferroportin (FPN) to inhibit dietary iron absorption and...

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Literature Corpus work: 9d83f399-ac7c-527a-8039-29f3d7ac771e
DOI: 10.1182/blood-2020-141148

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