Bid Regulates the Pathogenesis of Neurotropic Reovirus

Abstract excerpt

Reovirus infection leads to apoptosis in both cultured cells and the murine central nervous system (CNS). NF-kappaB-driven transcription of proapoptotic cellular genes is required for the effector phase of the apoptotic response. Although both extrinsic death-receptor signaling pathways and intrinsic pathways involving mitochondrial injury are implicated in reovirus-induced apoptosis, mechanisms by which either...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anesthesia and Neurotoxicity Research
• Share to Cell death mechanisms and regulation
• Share to Viral gastroenteritis research and epidemiology