Article

A genome-wide polygenic approach to HIV acquisition uncovers link to inflammatory bowel disease and identifies potential novel genetic variants

2017-06-12

Abstract excerpt

Polygenic approaches using genome-wide data have been hugely successful in confirming and quantifying the heritability of complex human traits. Here, we highlight their ability to identify potential novel risk variants by looking for variants with pleiotropic effect in genetically overlapping phenotypes. We used LD Score Regression in a sample of 6,315 HIV+ European individuals and 7,247 controls to test for pheno...

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Literature Corpus work: 9d69b0e8-9393-57a9-ac7f-f8b49e51e753
DOI: 10.1101/145383

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