Article

Genetic association of lipids and lipid-lowering drug targets with the risk of type 1 diabetes and its complications

2024-06-20

Abstract excerpt

<title>Abstract</title> <p>Purpose To evaluate causal effects of lipid traits and lipid-lowering drug targets on the risk of type 1 diabetes (T1D) and its complications. Methods Our study conducted two-sample and drug-target Mendelian randomization (MR) to assess the genetic association of lipid traits and lipid-lowering drug targets with the type 1 diabetes risk, respectively. For significant lipid-modifying d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d5e8bc7-5cc5-5b6a-88cd-0a4d7e194479
DOI: 10.21203/rs.3.rs-4537908/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic association of lipids and lipid-lowering drug targets with the risk of type 1 diabetes and its complicationsDOI 10.21203/rs.3.rs-4537908/v1Read

Drug targets for lipid modification and risk of type 2 diabetes: a cis-Mendelian randomization study.Semantic proximity Read

Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease.Semantic proximity Read

Causal effects of lipid-lowering therapies on aging-related outcomes and risk of cancers: a drug-target Mendelian randomization study.Semantic proximity Read

Based on systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for diabetes.Semantic proximity Read

Identification of lipid-modifying drug targets for autoimmune diseases: insights from drug target mendelian randomization.Semantic proximity Read

Genetic Association between Lipid-Regulating Drug Targets and Diabetic Retinopathy: A Drug Target Mendelian Randomization StudySemantic proximity Read

Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization studySemantic proximity Read

Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomizationSemantic proximity Read

Blood lipid profile, HbA1c, fasting glucose, and diabetes: a cohort study and a two-sample Mendelian randomization analysis.Semantic proximity Read

Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization study.Semantic proximity Read

Type 2 Diabetes and Adiposity Induce Different Lipid Profile Disorders: A Mendelian Randomization Analysis.Semantic proximity Read

Association between type 2 diabetes mellitus complications and NAFLD: Insights from the NHANES 2017-2020 and Mendelian randomization studySemantic proximity Read