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Inhibition of the T2R/α-Defensin Pathway Mediates <em>Nauclea officinalis</em>-Induced Intestinal Barrier Dysfunction and Microbiota Alterations

2025-12-16

Abstract excerpt

Clinical reports have shown that administration of Nauclea officinalis (Danmu in Chinese, DM) preparations may cause significant gastrointestinal discomfort. This study aimed to systematically evaluate the adverse effects of DM and its primary active constituent, strictosamide, on gastrointestinal motility, intestinal barrier integrity, and gut microbiota homeostasis. Furthermore, we sought to investigate the pote...

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Literature Corpus work
9cde615c-c3d3-5bd6-8112-83394e4dc586
DOI
10.20944/preprints202512.1325.v1
Open publication

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Inhibition of the T2R/α-Defensin Pathway Mediates <em>Nauclea officinalis</em>-Induced Intestinal Barrier Dysfunction and Microbiota AlterationsDOI 10.20944/preprints202512.1325.v1
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