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Article

Combination of clinicopathological and MRI based radiomics features in predicting homologous recombination repair genes mutations in prostate cancer.

Magnetic resonance imaging - 1 Dec 2025

Chen Ruchuan, Hu Guoqing, Zhou Bingni, Gan Hualei, Liu Xiaofeng, Deng Lin, Zhou Liangping, Gu Yajia, Liu Xiaohang

Abstract excerpt

PURPOSE: To develop Homologous Recombination Repair (HRR) Genes mutations prediction models for prostate cancer using MRI radiomics and clinicopathological features. METHODS: Totally 353 prostate cancer patients (102 with HRR genes mutations) from three centers (center 1: training and internal test cohorts, center 2 and 3: external test cohorts) underwent multiparametric MRI. Each patient's index tumor lesion was...

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Topics

Humans
Male
Prostatic Neoplasms
Mutation
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Recombinational DNA Repair

Prostate

Support Vector Machine

Radiomics

Source

Identifiers

PMID: 41076201
DOI: 10.1016/j.mri.2025.110534

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