Dopaminergic Dysregulation in Migraine: From Hypothalamic A11 Dysfunction to a Systemic Biobehavioral Phenotype.

doi:10.3390/ijms27167262

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Article

Dopaminergic Dysregulation in Migraine: From Hypothalamic A11 Dysfunction to a Systemic Biobehavioral Phenotype.

International journal of molecular sciences - 14 Aug 2026

Przegrałek Jakub, Targosiński Filip, Marschollek Karol, Łaczmańska Izabela, Pellesi Lanfranco, Budrewicz Sławomir, Nowakowska-Kotas Marta, Waliszewska-Prosół Marta

Abstract excerpt

Beyond the well-established roles of serotonin and calcitonin gene-related peptide (CGRP), the contribution of dopamine (DA) to migraine pathophysiology remains a subject of intense investigation. DA acts as a neuromodulator, functioning both as a homeostatic pain filter and a driver of premonitory and autonomic symptoms. This review provides a comprehensive synthesis of DA's involvement in migraine, proposing an...

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PMID: 42653268
DOI: 10.3390/ijms27167262
PMCID: PMC13513746

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