Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary Alpha-Tryptasemia: UK Prevalence and Variability in Disease Expression.

The journal of allergy and clinical immunology. In practice - 1 Jan 2000

Robey Rebecca C, Wilcock Amy, Bonin Hope, Beaman Glenda, Myers Bethan, Grattan Clive, Briggs Tracy A, Arkwright Peter D

Abstract excerpt

BACKGROUND: Hereditary alpha-tryptasemia (HAT) is a genetic trait caused by an increased alpha-tryptase tryptase alpha/beta 1 gene copy number. Basal serum mast cell tryptase (MCT) level is typically greater than or equal to 8.0 ng/mL. OBJECTIVES: To study the clinical disease spectrum of HAT and determine its UK prevalence. METHODS: Droplet digital PCR was used to determine tryptase alpha/beta 1 copy number in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hypersensitivity
Share to Hypertrophic osteoarthropathy and related conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast Cells

Share to Mast cells and histamine

Share to Phenotype

Share to Prevalence

Share to Tryptases

Share to United Kingdom

Source

Identifiers

PMID: 32553831
DOI: 10.1016/j.jaip.2020.05.057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary Alpha-Tryptasemia: UK Prevalence and Variability in Disease Expression.PMID 32553831Read ↗

Hereditary Alpha-Tryptasemia and Mastocytosis: What We Know and What We Need To Learn.Semantic proximity Read ↗

Hereditary alpha tryptasemia is not associated with specific clinical phenotypes.Semantic proximity Read ↗

Hereditary alpha-tryptasemiaSemantic proximity Read ↗

The Clinical Features of Hereditary Alpha-Tryptasemia—Implications for Interdisciplinary Practice.Semantic proximity Read ↗

Intra familial expression of Alpha tryptasemiaSemantic proximity Read ↗

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1.Semantic proximity Read ↗

Hereditary α-tryptasemia is Associated With Anaphylaxis to Antibiotics and Monoclonal Antibodies.Semantic proximity Read ↗

Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarkerSemantic proximity Read ↗

Hereditary Alpha-Tryptasemia: a Commonly Inherited Modifier of Anaphylaxis.Semantic proximity Read ↗

Incorporating Tryptase Genotyping Into the Workup and Diagnosis of Mast Cell Diseases and Reactions.Semantic proximity Read ↗

Hereditary alpha-tryptasemia modifies clinical phenotypes among individuals with congenital hypermobility disordersSemantic proximity Read ↗

Clinical impact of the TPSAB1 genotype in mast cell diseases: A REMA study in a cohort of 959 individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.