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Concurrent Gabapentin and Dihydropyridine Calcium Channel Blocker Use and Risk of Incident Dementia: An Active-Comparator Cohort Study

2026-02-09

Abstract excerpt

<h4>Importance</h4> Gabapentin and dihydropyridine calcium channel blockers (DHP CCBs) are commonly prescribed together in older adults: gabapentin reaches more than 15.5 million U.S. patients annually, and DHP CCBs such as amlodipine are a first-line antihypertensive class. Both classes act on neuronal calcium signaling, raising the question of whether their combined use is associated with greater cognitive risk...

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Literature Corpus work
9c0c05f1-3aad-5c81-bb97-aa1d05e4b3a8
DOI
10.64898/2026.02.06.26345763
Open publication

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Concurrent Gabapentin and Dihydropyridine Calcium Channel Blocker Use and Risk of Incident Dementia: An Active-Comparator Cohort StudyDOI 10.64898/2026.02.06.26345763
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