Article

Estrogen Receptor α/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

2024-04-27

Abstract excerpt

<h4>Summary</h4> Endocrine resistance in breast cancer treatment is a major clinical hurdle, causing an urgent need for alternative treatment modalities. The suppressive protein-protein interaction (PPI) between Estrogen Receptor alpha (ERα) and the adaptor protein 14-3-3 offers such a strategy. Here, we report the biological impact of small-molecule ‘molecular glues’ of this ERα/14-3-3 PPI by using both fusicocc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c0471ee-cab8-5173-a6bc-1fcc0323d9fc
DOI: 10.1101/2024.04.25.591105

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Estrogen Receptor α/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancerDOI 10.1101/2024.04.25.591105Read

Cooperative stabilisation of 14-3-3σ protein–protein interactions via covalent protein modificationSemantic proximity Read

Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as Novel Inhibitor for ELF3-MED23 InteractionSemantic proximity Read

Acetyl-cinobufagin Suppresses Triple Negative Breast Cancer Progression by Inhibiting the STAT3 PathwaySemantic proximity Read

Discovery of 14‐3‐3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug‐Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693Semantic proximity Read

GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancersSemantic proximity Read

Harnessing the 14-3-3 protein–protein interaction networkSemantic proximity Read

STAT 1 facilitates oestrogen receptor α transcription and stimulates breast cancer cell proliferationSemantic proximity Read

Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer.Semantic proximity Read

Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In VivoSemantic proximity Read

Steroid receptor coactivator-3 as a potential molecular target for cancer therapySemantic proximity Read

Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance.Semantic proximity Read

Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment.Semantic proximity Read