Article
Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors.
Molecular psychiatry - 1 Oct 2018
Cruceanu C, Schmouth J-F, Torres-Platas S G, Lopez J P, Ambalavanan A, Darcq E, Gross F, Breton B, Spiegelman D, Rochefort D, Hince P, Petite J M, Gauthier J, Lafrenière R G, Dion P A, Greenwood C M, Kieffer B L, Alda M, Turecki G, Rouleau G A
Abstract excerpt
Bipolar disorder (BD) is a prevalent mood disorder that tends to cluster in families. Despite high heritability estimates, few genetic susceptibility factors have been identified over decades of genetic research. One possible interpretation for the shortcomings of previous studies to detect causative genes is that BD is caused by highly penetrant rare variants in many genes. We explored this hypothesis by...
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