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Comparative Single-Cell Transcriptomics Uncovers Shared and Distinct Molecular Signatures in Cystic Fibrosis and Primary Ciliary Dyskinesia

2025-11-17

Abstract excerpt

<h4>Rational</h4> Cystic Fibrosis (CF) and Primary Ciliary Dyskinesia (PCD) are both inherited respiratory disorders that result in impaired mucociliary clearance, and chronic sinopulmonary disease. Although the current approach to PCD management is extrapolated from CF care, both conditions arise from distinct genetic and molecular mechanisms. <h4>Methods</h4> Here we performed a comparative transcriptomic anal...

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Literature Corpus work
9b988dd5-2edd-5a0d-831d-94b922822276
DOI
10.1101/2025.11.17.688876
Open publication

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Comparative Single-Cell Transcriptomics Uncovers Shared and Distinct Molecular Signatures in Cystic Fibrosis and Primary Ciliary DyskinesiaDOI 10.1101/2025.11.17.688876
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