Integrating cellular experiments, single-cell sequencing, and machine learning to identify endoplasmic reticulum stress biomarkers in idiopathic pulmonary fibrosis

Abstract excerpt

Background Idiopathic Pulmonary Fibrosis (IPF) presents a severe respiratory challenge with a poor prognosis due to the lack of reliable biomarkers. Recent evidence suggests that Endoplasmic Reticulum Stress (ERS) may be associated with IPF pathogenesis. This study focuses on uncovering ERS-associated biomarkers for IPF.Methods Sequencing data from diverse datasets were analyzed, utilizing differential gene...

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• Cystic Fibrosis Research Advances
• Endoplasmic Reticulum Stress and Disease
• Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis