Article

Integrative Transcriptomic Analysis Reveals Molecular Signatures and Candidate Therapeutic Targets for Primary Ciliary Dyskinesia

2026-01-14

Abstract excerpt

Primary ciliary dyskinesia (PCD) is a rare genetic disorder arising from motile cilia dysfunction, causing chronic respiratory infections, bronchiectasis, and progressive lung damage. We analysed the GSE25186 microarray dataset (6 PCD vs. 9 controls, Illumina HumanHT-12 V3.0, GPL6947) using an empirical-Bayes moderated t-test with sex-covariate correction. After Benjamini-Hochberg adjustment, 176 genes were differ...

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Literature Corpus work: 423f1eac-c683-5db8-b6af-1ee583ffec19
DOI: 10.64898/2026.01.12.26343910

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