Article

MutSigCVsyn: Identification of Thirty Synonymous Cancer Drivers

2022-01-18

Abstract excerpt

Synonymous mutations, which change only the DNA sequence but not the encoded protein sequence, can affect protein structure and function, mRNA maturation, and mRNA half-lives. The possibility that synonymous mutations can act as cancer drivers has been explored in several recent studies. However, none of these studies control for all three levels (patient, histology, and gene) of mutational heterogeneity that are...

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Literature Corpus work: 9b749e50-3004-5e2f-a99d-e88b3cebf558
DOI: 10.1101/2022.01.16.476507

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