Article

Enhancing Glycan Stability via Site-Selective Fluorination: Modulating Substrate Orientation by Molecular Design.

2020-07-15

Abstract excerpt

Single site OH to F substitution at the termini of maltotetraose leads to significantly improved hydrolytic stability towards alpha-amylase and alpha-glucosidase relative to the natural compound. Stability enhancements of around 1 order of magnitide result from these subtle point mutations. In both scenarios, modification of the monosaccharide furthest from the site of enzymatic cleavage leads to the greatest impr...

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Literature Corpus work: 9b6f8fc4-305e-5c01-8db5-bdebd7168fae
DOI: 10.26434/chemrxiv.12656210.v1

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