Chlorpromazine Overcomes Temozolomide Resistance in Glioblastoma by inhibiting Cx43 and Essential DNA Repair Pathways

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising candidate for repositioning in GBM therapy in addition to temozolomide, the first-line standard of care. We previously demonstrated the antitumor efficacy of c...

Topics

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• Annexin A5
• Antineoplastic Agents, Alkylating
• Connexin 43
• Cytochromes c
• Dacarbazine
• Fluoresceins
• Glioma
• Temozolomide

Identifiers and source

Literature Corpus work

9b6ad617-bebb-568b-9bc3-d6f2ce307aa9

DOI

10.21203/rs.3.rs-4376376/v1