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Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential

2025-05-06

Abstract excerpt

Phages are typically classified as temperate, integrating into host genomes, or lytic, replicating and killing bacteria. Lytic phages are not expected in bacterial genome sequences, yet our analysis of 3.6 million bacterial assemblies from 1,226 species revealed >100,000 complete lytic phage genomes, which we term Bacterial Assembly-associated Phage Sequences (BAPS). This represents a ∼five-fold increase in the nu...

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Literature Corpus work: 1a79fbfd-97a9-5a10-a42f-56d021f9a737
DOI: 10.1101/2025.05.06.652010

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