Article

Dysregulated DNA Methylation in Retinal Pigment Epithelium During the Early Stage of Stargardt Disease

2025-09-02

Abstract excerpt

Stargardt disease (STGD1), the most common inherited juvenile macular degeneration, is caused by biallelic mutations in the ABCA4 gene. Currently, there is no approved treatment. In this study, we investigated early-stage epigenomic changes in the retinal pigment epithelium (RPE) of Abca4-/- mice, a well-established model of STGD1. Reduced representation bisulfite sequencing (RRBS) revealed hypermethylation of gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b30265a-1fd2-5070-a23b-48ae3107e25a
DOI: 10.20944/preprints202509.0141.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysregulated DNA Methylation in Retinal Pigment Epithelium During the Early Stage of Stargardt DiseaseDOI 10.20944/preprints202509.0141.v1Read

DNA methylation plays important roles in retinal development and diseasesSemantic proximity Read

Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genesSemantic proximity Read

DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated DisordersSemantic proximity Read

Advances in Ophthalmic Epigenetics and Implications for Epigenetic Therapies: A ReviewSemantic proximity Read

Epigenetic Mechanisms of the Aging Human RetinaSemantic proximity Read

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental DynamicsSemantic proximity Read

Genetics and epigenetics of human retinoblastoma.Semantic proximity Read

DNA demethylation is a driver for chick retina regenerationSemantic proximity Read

QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degenerationSemantic proximity Read

Dnmt1, Dnmt3a and Dnmt3b cooperate in photoreceptor and outer plexiform layer development in the mammalian retina.Semantic proximity Read

Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesisSemantic proximity Read

Single-cell analysis of the epigenome and 3D chromatin architecture in the human retinaSemantic proximity Read