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DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders

12 Sept 2017

Abstract excerpt

This work provides a comprehensive CpG methylation landscape of the different layers of the human eye that unveils the gene networks associated with their biological functions and how these are disrupted in common visual disorders. Herein, we firstly determined the role of CpG methylation in the regulation of ocular tissue-specification and described hypermethylation of retinal transcription factors (i.e., PAX6,...

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PMID: 28924151
DOI: 10.1038/s41598-017-12084-1

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