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Article

Cryo-EM structure of the polycystin 2-l1 ion channel

13 Jul 2018

Abstract excerpt

We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability...

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PMID: 30004384
DOI: 10.7554/elife.36931

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