Article

T cell plasticity in systemic lupus erythematosus revealed by large-scale T cell receptor repertoire and transcriptome studies

2025-01-06

Abstract excerpt

CD4+ T cell plasticity plays a pivotal role in immune homeostasis. However, evidence of T cell plasticity and its pathological role in human systemic lupus erythematosus (SLE) is missing due to the lack of a reporter system. Here we utilized T cell receptor (TCR) repertoire data as a molecular signatures alongside transcriptomic dataset. Using a large-scale ImmuNexUT database of autoimmune disease patients includi...

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Literature Corpus work: 9aee2441-ebec-5513-b031-181d8b42ae6a
DOI: 10.1101/2025.01.06.24319648

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