Article

BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise

2025-06-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Disease heterogeneity is a persistent challenge in medicine, complicating both research and treatment. Standard analytical pipelines often assume patient populations are homogeneous, overlooking variance patterns that may signal biologically distinct subgroups. Variance heterogeneity (VH)—including skewness, outliers, and multimodal distributions—offers a powerful but underu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ac24e93-7b85-5337-b633-61a74108ef19
DOI: 10.1101/2025.06.01.657083

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as NoiseDOI 10.1101/2025.06.01.657083Read

Umpire 2.0: Simulating realistic, mixed-type, clinical data for machine learningSemantic proximity Read

ReDisX: a Continuous Max Flow-based framework to redefine the diagnosis of diseases based on identified patterns of genomic signaturesSemantic proximity Read

Heterogeneity in Statistics: A Conceptual and Methodological ReviewSemantic proximity Read

Disagreement between demultiplexing methods reveals structured cell quality gradients in multiplexed single-cell dataSemantic proximity Read

A general kernel machine comparative analysis framework for randomized block designsSemantic proximity Read

Qluster: An Easy-to-Implement Generic Workflow for Robust Clustering of Health DataSemantic proximity Read

A leakage-controlled stress-test framework for unsupervised cardiometabolic biomarker phenotyping in NHANESSemantic proximity Read

Capturing heterogeneity in gene expression studies by surrogate variable analysis.Semantic proximity Read

Analytical perturbation reveals hidden instability of biological phenotypesSemantic proximity Read

Finding associations in a heterogeneous setting: Statistical test for aberration enrichmentSemantic proximity Read

sctrial: Participant-Level Differential Analysis for Longitudinal Single-Cell ExperimentsSemantic proximity Read

variancePartition: Interpreting drivers of variation in complex gene expression studiesSemantic proximity Read