Article

A leakage-controlled stress-test framework for unsupervised cardiometabolic biomarker phenotyping in NHANES

2026-06-03

Abstract excerpt

<title>Abstract</title> <p>Background: Threshold-based cardiometabolic labels are indispensable for clinical communication, but they compress continuous multivariable physiology into a limited set of cut points. Unsupervised phenotyping can describe latent biomarker structure, but biomedical clustering requires rigorous leakage control, stability testing, robustness analysis, and replication before interpretation...

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Literature Corpus work: c01626e1-40ad-5262-bb28-3852babdf21c
DOI: 10.21203/rs.3.rs-9889895/v1

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