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Enhanced Loading of Paclitaxel in Cationic Liposomes by Replacement of Oleoyl with Linoleoyl Lipid Tails with Benefits in Cancer Therapeutics from <i>In Vitro</i> Studies

2020-10-12

Abstract excerpt

Lipid-based carriers of the hydrophobic drug paclitaxel (PTX) are used in clinical trials as next-generation agents for cancer chemotherapy. Improving the loading capacity of these carriers requires enhanced PTX solubilization. We compared the solubility of PTX in cationic liposomes (CLs) with lipid tails containing one (oleoyl; C18:1 Δ 9 ; DOTAP/DOPC) or two (linoleoyl; C18:2 Δ 9 ; DLinTAP/DLinPC) cis double b...

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Literature Corpus work
9abc09a0-971a-5955-a02c-3ca7d4c9891e
DOI
10.1101/2020.10.12.336412
Open publication

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Enhanced Loading of Paclitaxel in Cationic Liposomes by Replacement of Oleoyl with Linoleoyl Lipid Tails with Benefits in Cancer Therapeutics from <i>In Vitro</i> StudiesDOI 10.1101/2020.10.12.336412
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